The Thousand Autumns of Jacob de Zoet: A Novel

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• ISBN13: 9780812976366

Description

The year is 1799, the place Dejima in Nagasaki Harbor, the Japanese Empire’s single port and sole window onto the world, designed to keep the West at bay. To this place of devious merchants, deceitful interpreters, and costly courtesans comes Jacob de Zoet, a devout young clerk who has five years in the East to earn a fortune of sufficient size to win the hand of his wealthy fiancée back in Holland. But Jacob’s original intentions are eclipsed after a chance encounter with Orito Aibagawa, the disfigured midwife to the city’s powerful magistrate. The borders between propriety, profit, and pleasure blur until Jacob finds his vision clouded, one rash promise made and then fatefully broken—the consequences of which will extend beyond Jacob’s worst imaginings.

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Amazon Best Books of the Month, July 2010: David Mitchell reinvents himself with each book, and it's thrilling to watch. His novels like Ghostwritten and Cloud Atlas spill over with narrators and language, collecting storylines connected more in spirit than in fact. In The Thousand Autumns of Jacob de Zoet, he harnesses that plenitude into a more traditional form, a historical novel set in Japan at the turn into the 19th century, when the island nation was almost entirely cut off from the West except for a tiny, quarantined Dutch outpost. Jacob is a pious but not unappealing prig from Zeeland, whose self-driven duty to blurt the truth in a corrupt and deceitful trading culture, along with his headlong love for a local midwife, provides the early engine for the story, which is confined at first to the Dutch enclave but crosses before long to the mainland. Every page is overfull with language, events, and characters, exuberantly saturated in the details of the time and the place but told from a knowing and undeniably modern perspective. It's a story that seems to contain a thousand worlds in one. --Tom Nissley

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Secret Life: Firsthand, Documented Accounts of Ufo Abductions

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• ISBN13: 9780671797201
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Description

In Secret Life, Professor David M. Jacobs of Temple University takes us into the private world of those abducted by aliens, letting them describe in their own words what it is like to be abducted. Based on interviews with sixty individuals and more than 300 independently corroborated accounts, Secret Life presents the most complete and accurate picture of alien abductions ever compiled. Dr. Jacobs takes the reader on a minute-by-minute journey through a typical abduction experience and describes in detail the bizarre physical, mental and reproductive procedures that abductees claim have been administered by small alien beings. Jacobs draws from these interviews a profoundly unsettling reason behind the abductions: aliens are conducting a complex reproductive experiment involving the conception, gestation. or incubation of human and alien hybrid beings.

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The THREAT: Revealing the Secret Alien Agenda

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• ISBN13: 9780684848136
• Up: New
• Notes: Trade mark NEW FROM PUBLISHER! 100% Satisfaction Guarantee. Tracking provided on most orders. Buy with Confidence! Millions of books sold!

Description

The world's foremost academic expert on UFOs and alien abductions provides the first evidence-based explanation of a mystery that has perplexed scientists for decades.

Based on more than 700 hypnotic-regression interviews with alien abductees and a Roper survey of 6,000 adults, The Threat reveals why the aliens are here and what they want, explains why their agenda has been kept secret, and exposes their frightening plans for earth and its inhabitants. In a direct, authoritative challenge to researchers who believe the abduction phenomenon is essentially benevolent and spiritually uplifting, Professor David M. Jacobs proves that there is a far more disturbing and potentially dangerous plan underway, with possible alien domination at its core.

In this remarkably well-researched and well-written book, Professor Jacob has added a new complexity and depth to our knowledge of the UFO and abduction phenomena. The secret alien agenda revealed here is ominous, but it must be confronted before it is too late.

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Effectiveness and Safety of Diclofenac Epolamine Topical Patch 1.3% for the Treatment of Acute Pain Due to Back Strain: An Open-Label, Uncontrolled Study ... (The Physician and Sportsmedicine)

Description

Background:

The diclofenac epolamine topical patch 1.3% (DETP) is indicated for topical treatment of acute pain due to minor strains, sprains, and contusions. This exploratory, multicenter, open-label study evaluated effectiveness and safety of DETP in patients with acute pain due to back strain.

Methods:

Patients aged ≥ 18 years with acute pain due to nonradicular back strain with an average pain intensity of ≥ 4 (0 = no pain, 10 = pain as bad as you can imagine) entered a 3-day observation/washout period and completed daily diary modified Brief Pain Inventory assessments. At baseline, patients with an average pain intensity of ≥ 4 started DETP treatment (q12h). Patients were treated for 7 or 14 days, depending on investigator and patient assessment of pain resolution. Primary endpoint was mean change from baseline to end of treatment in average pain intensity. Key secondary endpoints included changes from baseline in least, worst, and current pain scores and Beck Depression Inventory® II scores. Patients and investigators assessed patch satisfaction and global pain relief.

Results:

In 123 enrolled patients, baseline mean ± standard deviation average pain score was 6.5 ± 1.3, which decreased to 2.5 ± 2.4 (P < 0.0001) at end of treatment. Similarly, least, worst, and current pain scores were also reduced (P < 0.0001). Sixty-three percent of patients achieved ≥ 50% pain reduction from baseline. At the end of treatment, most patients (88%) were satisfied or very satisfied with DETP. For 85% of patients, investigators also reported being satisfied or very satisfied with DETP. Most patients (87%) and investigators (88%, rating the patient’s response) rated global pain relief as moderate to complete. Fifteen patients experienced a total of 19 adverse events (AEs), 17 of which were mild to moderate, and 2 of which were severe. Three AEs were treatment related (application site rash, nausea, and tachycardia); 1 patient had a serious AE (noncardiac chest pain) considered unrelated to DETP.

Conclusion:

In this exploratory study, patients experienced well-tolerated relief for acute pain due to back strain, with ≥ 85% of patients and their investigators expressing satisfaction with DETP treatment.

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Background:

The diclofenac epolamine topical patch 1.3% (DETP) is indicated for topical treatment of acute pain due to minor strains, sprains, and contusions. This exploratory, multicenter, open-label study evaluated effectiveness and safety of DETP in patients with acute pain due to back strain.

Methods:

Patients aged ≥ 18 years with acute pain due to nonradicular back strain with an average pain intensity of ≥ 4 (0 = no pain, 10 = pain as bad as you can imagine) entered a 3-day observation/washout period and completed daily diary modified Brief Pain Inventory assessments. At baseline, patients with an average pain intensity of ≥ 4 started DETP treatment (q12h). Patients were treated for 7 or 14 days, depending on investigator and patient assessment of pain resolution. Primary endpoint was mean change from baseline to end of treatment in average pain intensity. Key secondary endpoints included changes from baseline in least, worst, and current pain scores and Beck Depression Inventory® II scores. Patients and investigators assessed patch satisfaction and global pain relief.

Results:

In 123 enrolled patients, baseline mean ± standard deviation average pain score was 6.5 ± 1.3, which decreased to 2.5 ± 2.4 (P < 0.0001) at end of treatment. Similarly, least, worst, and current pain scores were also reduced (P < 0.0001). Sixty-three percent of patients achieved ≥ 50% pain reduction from baseline. At the end of treatment, most patients (88%) were satisfied or very satisfied with DETP. For 85% of patients, investigators also reported being satisfied or very satisfied with DETP. Most patients (87%) and investigators (88%, rating the patient’s response) rated global pain relief as moderate to complete. Fifteen patients experienced a total of 19 adverse events (AEs), 17 of which were mild to moderate, and 2 of which were severe. Three AEs were treatment related (application site rash, nausea, and tachycardia); 1 patient had a serious AE (noncardiac chest pain) considered unrelated to DETP.

Conclusion:

In this exploratory study, patients experienced well-tolerated relief for acute pain due to back strain, with ≥ 85% of patients and their investigators expressing satisfaction with DETP treatment.

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Jacob: The Fools God Chooses

Description

In unfathomable love, God chooses foolish, self-serving human beings and fits them for His divine purposes. In Jacobs case, God transformed His ""fool"" into a great nation in spite of Jacob's many flaws, his devious, manipulative, and selfish ways. What worked in Jacobs favor, according to author David Roper, was that Jacob wanted God. ""God does not foist himself on those who do not want Him,"" Roper writes, ""but he diligently looks for those who do, no matter who they are or what they have done. In seventeen chapters, with titles such as ""The Birthright,"" ""Jacob's Ladder,"" and ""The Cleansing Flame,"" Roper offers candid snap- shots of God's handiwork in the life of this schemer-turned-patriarch.

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Jacob's Legacy: A Genetic View of Jewish History

Description

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